string(4) "test" RECONSTRUCTIVE FLAP SURGERY IN HEAD AND NECK CANCER PATIENTS: CHALLENGES IN POSTOPERATIVE RADIOTHERAPY FROM AN INTERDISCIPLINARY PERSPECTIVE OF RADIATION ONCOLOGISTS | International Conference On Higher Education Teaching
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Vol. 3 No. 2 (2025)
International Conference On Higher Education Teaching

Articles

RECONSTRUCTIVE FLAP SURGERY IN HEAD AND NECK CANCER PATIENTS: CHALLENGES IN POSTOPERATIVE RADIOTHERAPY FROM AN INTERDISCIPLINARY PERSPECTIVE OF RADIATION ONCOLOGISTS

Published 2025-02-20

  • Nishanbayeva Firuza Murodovna

Abstract

Over the past two decades, significant advancements have been made in the surgical, radiotherapeutic, systemic, and supportive care of head and neck cancer (HNC). Despite these improvements, more than 75% of HNC patients are diagnosed at advanced stages and often require multimodal treatment strategies. While combined treatment approaches are essential to maximize the chances of cure, they also contribute to cumulative late toxicities. Surgery remains a cornerstone of HNC treatment, with approximately 60% of patients undergoing radiotherapy, either as part of definitive (chemo)radiotherapy or in the postoperative setting (poRT).

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References

  1. Siegel RL, Miller KD, Wagle NS, Jemal A. Cancer statistics, 2023. CA: A Cancer J Clin. (2023) 73:17–48. doi: 10.3322/caac.21763 [DOI] [PubMed] [Google Scholar]
  2. Machtay M, Moughan J, Trotti A, Garden AS, Weber RS, Cooper JS, et al. Factors associated with severe late toxicity after concurrent chemoradiation for locally advanced head and neck cancer: an RTOG analysis. J Clin Oncol. (2008) 26:3582–9. doi: 10.1200/JCO.2007.14.8841 [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Mody MD, Rocco JW, Yom SS, Haddad RI, Saba NF. Head and neck cancer. Lancet. (2021) 398:2289–99. doi: 10.1016/S0140-6736(21)01550-6 [DOI] [PubMed] [Google Scholar]
  4. Mehanna H, Wong WL, Dunn J. Management of advanced nodal disease in patients treated with primary chemoradiotherapy. Curr Opin Oncol. (2016) 28:201–4. doi: 10.1097/CCO.0000000000000283 [DOI] [PubMed] [Google Scholar]
  5. Nutting CM, Morden JP, Shreerang Urbano Harrington TGuerrero KJ, Bhide A, Clark C, et al. Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): a phase 3 multicentre randomised controlled trial. Lancet Oncol. (2011) 12:127–36. doi: 10.1016/S1470-2045(10)70290-4 [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Thiruchelvam PTR, Leff DR, Godden AR, Cleator S, Wood SH, Kirby AM, et al. Primary radiotherapy and deep inferior epigastric perforator flap reconstruction for patients with breast cancer (PRADA): a multicentre, prospective, non-randomised, feasibility study. Lancet Oncol. (2022) 23:682–90. doi: 10.1016/S1470-2045(22)00145-0 [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Carsuzaa F, Lapeyre M, Gregoire V, Maingon P, Beddok A, Marcy P-Y, et al. Recommendations for postoperative radiotherapy in head & neck squamous cell carcinoma in the presence of flaps: A GORTEC internationally-reviewed HNCIG-endorsed consensus. Radiother Oncol. (2021) 160:140–7. doi: 10.1016/j.radonc.2021.04.026 [DOI] [PubMed] [Google Scholar]
  8. Brown JS, Shaw RJ. Reconstruction of the maxilla and midface: introducing a new classification. Lancet Oncol. (2010) 11:1001–8. doi: 10.1016/S1470-2045(10)70113-3 [DOI] [PubMed] [Google Scholar]
  9. Seth R, Khan AA, Pencavel T, Harrington KJ, Harris PA. Targeted gene delivery by free-tissue transfer in oncoplastic reconstruction. Lancet Oncol. (2012) 13:e392–402. doi: 10.1016/S1470-2045(12)70235-8 [DOI] [PubMed] [Google Scholar]
  10. Cannon RB, Houlton JJ, Mendez E, Futran ND. Methods to reduce postoperative surgical site infections after head and neck oncology surgery. Lancet Oncol. (2017) 18:e405–13. doi: 10.1016/S1470-2045(17)30375-3 [DOI] [PubMed] [Google Scholar]